Neutrophils play important roles in the immune response against Mycobacterium tuberculosis infection
XIONG Kunlong1, CHENG Xunjia1, ZHANG Wenhong2, WANG Feifei1
1. Department of Medical Microbiology and Parasitology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China; 2. Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai 200040, China
Abstract：Tuberculosis is a global health concern. Cell-mediated immunity plays important roles against the infection. Several types of immune cells and cytokines play key roles in the pathogenesis, development and prognosis of tuberculosis through a variety of mechanisms. Neutrophils participate in constituting the first line of defense to Mycobacterium tuberculosis (M. tuberculosis). Neutrophils gather at the infection site rapidly after infection, and play the roles of anti-tuberculosis immunity through various mechanisms, such as phagocytosis, apoptosis, granuloma formation, neutrophil extracellular traps and producing effector cytokines. In addition, neutrophils also participate in the tissue injury process in tuberculosis patients. The recent research progress on the functions of neutrophils and some cytokines related to the immune response to tuberculosis is summarized.
熊坤龙1，程训佳1，张文宏2，王菲菲1. 中性粒细胞在抗结核免疫中的作用[J]. 微生物与感染, 2018, 13(3): 186-192.
XIONG Kunlong1, CHENG Xunjia1, ZHANG Wenhong2, WANG Feifei1. Neutrophils play important roles in the immune response against Mycobacterium tuberculosis infection. JOURNAL OF MICROBES AND INFECTIONS, 2018, 13(3): 186-192.
