Abstract:Chlamydia is an intracellular bacterium that infects many vertebrates, including humans. Previous studies have shown that interferon-γ(IFN-γ) plays an important role in defense against Chlamydia infection. IFN-γ-mediated anti-Chlamydia effector mechanisms may include the exhaustion of tryptophan, the induction of iron loss, and/or the activation of inducible nitric oxide synthase (iNOS). However, Chlamydia has evolved to develop mechanisms to escape IFN-γ functions. In this review, we will discuss IFN-γ-mediated effector mechanisms in the control of Chlamydia infection.
通讯作者:
吴移谋
引用本文:
唐国芳;李忠玉;吴移谋. γ干扰素抗衣原体感染作用的研究进展[J]. 微生物与感染
, 2009, 4(2): 103-107 .
TANG Guo-Fang;LI Zhong-Yu;WU Yi-Mou. Mechanism of interferon-γ-mediated anti-Chlamydia infection. Journal of Microbes and Infections, 2009, 4(2): 103-107 .