Current research progress on acid resistance mechanism of Mycobacterium tuberculosis
SHI Xu-Jun, WANG Qing-Lan, GAO Qian
Key Laboratory of Medical Molecular Virology, Ministry of Education and Health, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China
Abstract：The survival of Mycobacterium tuberculosis (M. tuberculosis) in the host is largely attributed to its ability to resist acidic environment within macrophages. M. tuberculosis inhibits the fusion of phagosomes with lysosomes, thus arresting the maturation and acidification process of phagosomes. Also, the bacterium resists the killing within the acidic phagosome-lysosome compartment. Here, the current understanding of the acidification of phagosomes and M. tuberculosis acid resistance mechanisms is reviewed.
施旭骏，王晴岚，高谦. 结核分枝杆菌耐酸机制的研究进展[J]. 微生物与感染
, 2013, 8(3): 192-196.
SHI Xu-Jun, WANG Qing-Lan, GAO Qian. Current research progress on acid resistance mechanism of Mycobacterium tuberculosis. Journal of Microbes and Infections, 2013, 8(3): 192-196.
