Potential impact of hypertension and angiotensin converting enzyme inhibitors treatment on severe acute respiratory syndrome coronavirus 2 susceptibility and prognosis
GU Keyi1，WANG Huijing1，ZHAO Chao2，3
1. Laboratory of Neuropsychopharmacology, School of Fundamental medicine, Shanghai University of Medicine & Health Sciences, Shanghai 201318, China; 2. MOE/NHC/CAMS Key Laboratory of Molecular Virology, School of Basic Medical Sciences, Shanghai Medical College, Fudan university, Shanghai 200032, China; 3. National Clinical Research Center on Aging and Medicine, Huashan Hospital, Shanghai 200041, China
Abstract：Two subgroups of coronavirus disease 2019(COVID-19) patients deserved special medical attention, one being hypertension patients, the other being hypertension patients treated with angiotensin converting enzyme inhibitors (ACEI). Relatively high susceptibility of hypertension patients to the disease and severe prognosis for the ones using ACEI indicate that there is a close relationship between virus infection and hypertension, which puts forward the demand for rational medication for the special group of patients with hypertension. In this paper, we analyzed the balance between angiotensin converting enzyme 2 (ACE2), the functional receptor of SARS-CoV-2, and ACE, and then discussed the relationship between hypertension and virus susceptibility, as well as the possible pathogenesis of COVID-19 in hypertension. Because the angiotensin converting enzyme inhibitors (ACEI) play an important role in the population of hypertension, we give guidance and suggestions on the medication of hypertension before and after virus infection in this population for clinical reference in this paper by the analysis of pharmacology and etiology.
2020, Vol. 15 
