Abstract:Human herpesvirus 6 ( HHV-6) , a double-stranded DNA virus, is amember of the β herpes subfamily. It has been hypothesized that the HHV-6 genome may code 80 to 100 different proteins, including membrane proteins, immediate early ( IE) proteins, DNA packaging proteins, and virus assembly proteins, etc. In this article, the research progress regarding the features and functions of proteins encoded by the HHV-6 gene is reviewed.