Abstract：After having gone through the bumpy road of the failure of first and second generations of human immunodeficiency virus ( HI V) vaccines , the first beamjust appeared recently . The goal of preventing HIV acquisitionis not unachievable , showing in the combined vaccine trial ( RV144) conducted in Thailand . With the progresses of obtaining better broad-spectrumneutralizing antibody and the development of its rystal structure , full protection achieved by genetic transferring of neutralizing antibodies , mosaic T cell epitope vaccines , as well as replicating viral vector vaccines , it is possible to achieve higher efficacy of vaccine protection. With the support of National Science and Technology Key Projects , scientists in the China HIV Vaccine Initiative are conducting innovative HI V vaccine research and also possible to make a big leap f orward , if seized the opportunity of international collaboration at the global and regional level .
邵一鸣. 全球人类免疫缺陷病毒疫苗研究的进展、挑战和我国的历史性机遇[J]. 微生物与感染
, 2010, 5(4): 193-198.
SHAO Yi-Ming . Advance and challenge in human immunodeficiency virus vaccine research and historic opportunity for China. Journal of Microbes and Infections, 2010, 5(4): 193-198.