Human leukocyte antigen-DP loci are associated with the persistent infection of hepatitis B virus in Chinese population
Yun Ling1,2,3; Liao Xiang-Wei1,2,3; Li Xin-Hua1,2,3; Han Yue1,2,3; Yang Zhi-Tao3; Kong Xiao-Fei1,2,3; Gu Lei-Lei1,2,3; Yu De-Ming1,2,3, ; Yao Bi-Lian3; Zhang Dong-Hua1,2,3; Jin Gen-Di1,2,3; Gong Qi-Ming1,2,3; Zhang Xin-Xin1,2,3
1. Department of Infectious Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; 2. Institute of Infectious and Respiratory Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; 3. Sino-French Laboratory of Life Science and Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
Human leukocyte antigen-DP loci are associated with the persistent infection of hepatitis B virus in Chinese population
Yun Ling1,2,3; Liao Xiang-Wei1,2,3; Li Xin-Hua1,2,3; Han Yue1,2,3; Yang Zhi-Tao3; Kong Xiao-Fei1,2,3; Gu Lei-Lei1,2,3; Yu De-Ming1,2,3, ; Yao Bi-Lian3; Zhang Dong-Hua1,2,3; Jin Gen-Di1,2,3; Gong Qi-Ming1,2,3; Zhang Xin-Xin1,2,3
1. Department of Infectious Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; 2. Institute of Infectious and Respiratory Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; 3. Sino-French Laboratory of Life Science and Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
摘要: A genome-wide association study recently showed that genetic variants in human leukocyte antigen (HLA)-DP loci were strongly associated with a risk of persistent infection of hepatitis B virus (HBV) in Japanese and Thai individuals and variants in interleukin 28B (IL-28B) have been associated with responses to anti-hepatitis C virus (HCV) treatment. The aim of this study was to investigate whether the HLA-DP loci and IL-28B were associated with different outcomes of chronic HBV infection (CHB) in Chinese subjects. The rs9277535 near HLA-DPB1,rs3077 near HLA-DPA1, and rs12979860 genotype near IL28B were genotyped by direct sequencing in 185 CHB patients and 193 self-limited hepatitis B virus (SLHBV)-infected subjects who recovered from HBV infection. The rs9277535 near HLA-DPB1 was strongly associated with CHB (P=0.0000181, OR=1.905). This association was observed independent of HBV e antigen (HBeAg) status and HBV viral loads in HBeAg-positive patients (P=0.0004, OR=1.956), in HBeAg-negative patients (P=0.0009, OR=1.857), and in HBeAg-negative individuals without detectable levels of HBV DNA in serum (P=0.0011, OR=2.05). The rs3077 near HLA-DPA1 was associated with CHB (P=0.0206, OR=0.6865) and HBeAg-positive infection status (P=0.0143, OR=0.6047). Meanwhile, a genetic variation of insertion-deletion (INDEL) polymorphism (rs361527, -/ATAAATGTTGA) near HLA-DPA1 was found to be associated with CHB (P=0.0307, OR=0.7028) and HBeAg-positive CHB infection status (P=0.0233, OR=0.619). However,the rs12979860 genotype near IL28B had no correlation with CHB. This study demonstrated that in the Han Chinese populations, HLA DP loci, but not IL-28B, was associated with persistence of infection in different outcomes of HBV infected patients; however, the mechanism needs to be further investigated.
Abstract:A genome-wide association study recently showed that genetic variants in human leukocyte antigen (HLA)-DP loci were strongly associated with a risk of persistent infection of hepatitis B virus (HBV) in Japanese and Thai individuals and variants in interleukin 28B (IL-28B) have been associated with responses to anti-hepatitis C virus (HCV) treatment. The aim of this study was to investigate whether the HLA-DP loci and IL-28B were associated with different outcomes of chronic HBV infection (CHB) in Chinese subjects. The rs9277535 near HLA-DPB1,rs3077 near HLA-DPA1, and rs12979860 genotype near IL28B were genotyped by direct sequencing in 185 CHB patients and 193 self-limited hepatitis B virus (SLHBV)-infected subjects who recovered from HBV infection. The rs9277535 near HLA-DPB1 was strongly associated with CHB (P=0.0000181, OR=1.905). This association was observed independent of HBV e antigen (HBeAg) status and HBV viral loads in HBeAg-positive patients (P=0.0004, OR=1.956), in HBeAg-negative patients (P=0.0009, OR=1.857), and in HBeAg-negative individuals without detectable levels of HBV DNA in serum (P=0.0011, OR=2.05). The rs3077 near HLA-DPA1 was associated with CHB (P=0.0206, OR=0.6865) and HBeAg-positive infection status (P=0.0143, OR=0.6047). Meanwhile, a genetic variation of insertion-deletion (INDEL) polymorphism (rs361527, -/ATAAATGTTGA) near HLA-DPA1 was found to be associated with CHB (P=0.0307, OR=0.7028) and HBeAg-positive CHB infection status (P=0.0233, OR=0.619). However,the rs12979860 genotype near IL28B had no correlation with CHB. This study demonstrated that in the Han Chinese populations, HLA DP loci, but not IL-28B, was associated with persistence of infection in different outcomes of HBV infected patients; however, the mechanism needs to be further investigated.
Yun Ling1,2,3; Liao Xiang-Wei1,2,3; Li Xin-Hua1,2,3; Han Yue1,2,3; Yang Zhi-T. Human leukocyte antigen-DP loci are associated with the persistent infection of hepatitis B virus in Chinese population[J]. 微生物与感染
, 2012, 7(1): 18-27.
Yun Ling1,2,3; Liao Xiang-Wei1,2,3; Li Xin-Hua1,2,3; Han Yue1,2,3; Yang Zhi-Tao3; Kong Xiao-Fei1,2,3; Gu Lei-Lei1,2,3; Yu De-Ming1,2,3, ; Yao Bi-Lian3; Zhang Dong-Hua1,2,3; Jin Gen-Di1,2,3; Gong Q. Human leukocyte antigen-DP loci are associated with the persistent infection of hepatitis B virus in Chinese population. Journal of Microbes and Infections, 2012, 7(1): 18-27.