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Current research progress on host innate immune escaping by Salmonella |
XU Nuo1, ZHOU Bangyue1, SHI Yi1, PAN Xingyuan1,2, QIN Tao3, XU Zhengzhong4, YIN Yinyan1,2,4 |
1. Institute of Translational Medicine, Medical College, Yangzhou University, Yangzhou 225009, Jiangsu Province, China; 2. Jiangsu Key laboratory of integrated traditional Chinese and Western Medicine for prevention and treatment of Senile Diseases, Yangzhou University, Yangzhou 225009, Jiangsu Province, China; 3. Jiangsu Co-Innovation Center for the Prevention and Control of Important Animal Infectious Disease and Zoonosis, College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, Jiangsu Province, China; 4. Jiangsu Key Laboratory of Zoonosis, Yangzhou University, Yangzhou 225009, Jiangsu Province, China |
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Abstract Salmonella is an important foodborne pathogen, which seriously threatens the global public health. The host innate immune response plays a significant role for resisting infection. Nowadays, Salmonella has evolved a series of strategies to escape the innate immune response for persistent infections. This review gives a detailed summarization on the new strategies of Salmonella, including receptors (TLRs, NLRs, RIPs), cytokines (IL-22 and IL-4) and mTOR signaling pathway-mediated immune escape.
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Received: 21 February 2020
Published: 25 October 2020
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Corresponding Authors:
YIN Yinyan
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