广西人类免疫缺陷病毒感染者/艾滋病患者合并马尔尼菲篮状菌感染的特征及Mp1p抗原快速筛检的研究

doi:10.3969/j.issn.1673-6184.2021.01.003

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Abstract The present paper aims to investigate the characteristics of human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) patients combined with Talaromyces marneffei (TM) infection in Guangxi Zhuang Autonomous Region, and to evaluate a TM antigen detection kit. The information of 200 HIV/AIDS patients including 20 patients combined with TM infection from Liuzhou People’s Hospital was collected. The overall TM infection rate was 10%, and TM infection rate was higher in the patients with lower CD4^＋ T counts. In the patients with CD4^＋ T counts ≤50/μL, TM infection rate could be as high as 29%. The CD4^＋ T count, lymphocyte, hemoglobin, albumin, and platelet levels in HIV/AIDS patients combined with TM infection were significantly lower than those HIV/AIDS patients without TM infection (P<0.001). In contrast aspartate aminotransferase (AST), AST/alanine aminotransferase (ALT) and D-dimer were significantly increased in HIV/AIDS patients combined with TM infection (P<0.05). A TM antigen detection kit was used to detect TM in 118 plasma samples and 111 pharyngeal swab samples, and the results were compared with pathogenic culture results. For plasma samples, the sensitivity was 80% (95% CI: 51.1-94.7) and the specificity was 97.1% (95% CI: 91.1-99.2). For pharyngeal swab samples, the sensitivity was 41.7% (95% CI: 16.5-71.4) and the specificity was 100% (95% CI: 0.95-1). The results showed that the TM antigen detection kit has good sensitivity and high specificity for plasma sample detection, which maybe suitable for the clinical screening of TM infection. It is recommended that HIV/AIDS patients with low CD4^＋ T counts should be screened for Mp1p antigen as soon as possible for early detection and early treatment, and to reduce the mortality.

Key words： Human immunodeficiency virus Acquired immunodeficiency syndrome Talaromyces marneffei Coinfection Mp1p antigen Double-antibody sandwich enzyme-linked immunosorbent assay

Received: 07 May 2020 Published: 25 February 2021

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R519.8　　

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Corresponding Authors: LIANG Hao，NING Chuanyi

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	HAN Jing
	JIANG Zhongsheng
	WANG Gang
	ZHANG Peng
	HU Jiaguang
	WEI Wudi
	ZHANG Hong
	HE Jinhao
	LI Yueqi
	NING Chuanyi
	LIANG Hao

Cite this article:

HAN Jing,JIANG Zhongsheng,WANG Gang等. Characteristics of human immunodeficiency virus/acquired immunodeficiency syndrome patients combined with Talaromyces marneffei infection in Guangxi and application of rapid screening of Mp1p antigen[J]. JOURNAL OF MICROBES AND INFECTIONS, 2021, 16(1): 19-25.

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http://jmi.fudan.edu.cn/EN/10.3969/j.issn.1673-6184.2021.01.003 OR http://jmi.fudan.edu.cn/EN/Y2021/V16/I1/19

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