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| The impact of micro RNAs on human immunodeficiency virus infection: A flying bullet to invader? |
| ZHU Ling-Yan1,2; QIU Chao1,3; XU Jian-Qing1,3,4 |
| 1. Shanghai Public Health Clinical Center Affiliated to Fudan University, Shanghai 201508, China; 2. Wenzhou Medical College, Wenzhou 325035, China; 3. The Institutes of Biomedical Sciences, Fudan University, Shanghai 201508, China; 4. Key Laboratory of Medical Molecular Virology of Ministry of Education and Health, Shanghai Medical College, Fudan University, Shanghai 200032, China |
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Abstract microRNAs (miRNAs) are endogenously derived small RNAs that regulate the expression of mRNA via binding to its target sequence at mRNA 3' -untranslated regions (UTRs) and thereby play an important role in many biological activities in host cells. Studies have shown that cellular miRNAs can regulate the expression of human immunodeficiency virus (HIV) and affect the replication and infection of HIV, and actively engage in the latency of HIV. Meanwhile, viral miRNAs produced by HIV-1 play an important role in regulating both the viral life cycle and the interaction between virus and host. However, more HIV-associated miRNAs remain to be discovered and their acting mechanisms need to be further addressed.
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Received: 23 February 2011
Published: 25 September 2011
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Corresponding Authors:
XU Jian-Qing
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