|
|
|
| Research progress on human immunodeficiency virus reservoir and its eradication |
| HE Yong-Quan, MENG Zhe-Feng, ZHANG Xiao-Yan |
| Shanghai Public Health Clinical Center Affiliated to Fudan University，Shanghai 201508, China |
|
|
|
|
Abstract Highly active antiretroviral therapy (HAART) has driven human immunodeficiency virus (HIV) to undetectably low levels in the blood and improved life quality of HIV / acquired immunodeficiency syndrome (AIDS) patients. However, the eradication of HIV-1 is hindered by the persistence of long-lived, latently infected memory CD4 T cells and the formation of viral reservoirs. Research on HIV reservoir eradication mainly focus on gene therapy , drug treatment targeting latently HIV-1-infected cells or directly reactivating the latent viruses, which are easier to be killed by antiviral therapy. In this review , the recent research progress on HIV reservoir and its eradication is summarized.
|
|
Received: 19 July 2012
Published: 25 December 2012
|
|
Corresponding Authors:
ZHANG Xiao-Yan
|
|
|
|
|
|
|
