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| Analysis of immune cells and liver biochemical markers in patients with HIV/HCV co-infection |
| SHEN Fang; CHEN Dai-hong; HUANG Qin; SUN Hong-qing; CHEN Shu; GAO Qiong |
| Shanghai Public Health Clinical Center, Shanghai 201508, China |
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Abstract Objective To explore the characteristics of immune lymphocyte subpopulation and liver biochemical markers in patients with HIV/HCV co-infection.Methods Some related laboratory makers of peripheral blood in the study group(40 hemophiliac patients with HIV/HCV co-infection)and in the control group(12 hemophiliac patients with HIV infection only)were detected and analyzed.Results There were significant differences between results of the two groups(study and the control)were in following:NK cell(9.26±5.98)% vs(12.19±5.80)%,P<0.05.The rate of CD4/CD8 0.39±0.21 vs 0.53±0.24,P<0.05.CD3(74.99±10.33)% vs(68.42±8.82)%,P<0.05.CD8(52.28±12.59)% vs(43.58±10.99)%,P<0.05.ALT(48.59±40.21)U/L vs(26.87±27.23)U/L,P<0.001.AST(61.66±51.02)U/L vs(34.17±30.24)U/L,P<0.001.GGT(136.50±111.50)U/L vs(43.88±36.17)U/L,P<0.001.CG(683.41±962.22)μg/dL vs(250.96±290.81)μg/dL,P<0.001.Hyaluronic acid(180.94±196.69)ng/mL vs(64.68±32.74)ng/mL,P<0.001.Albumin/globin(1.35±0.24)vs(1.50 ±0.34),P<0.05.Comparing with the patients infected with HIV only,NK cell,rates of CD4/CD8 and albumin/globin were decreased significantly,but the level of AST,ALT,GGT,CG,and liver fibrosis marker HA were increased significantly in the patients co-infected with HIV/HCV.Conclusion Patients co-infected with HIV/HCV may aggravate the imbalance of lymphocyte subpopulations,worsen liver injury and occur fibrosis tendency.
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Received: 01 January 1900
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Corresponding Authors:
SHEN Fang
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2007, Vol. 2 
