|
|
|
| Performance of interferon γ release assays in diagnosis of childhood pulmonary tuberculosis |
| BAO Lei1, LI Tao1,2, LU Shui-Hua2, ZHANG Wen-Hong1 |
| 1. Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai 200040, China; 2. Shanghai Public Health Clinical Center Affiliatd to Fudan University, Shanghai 201508, China |
|
|
|
|
Abstract In order to investigate the performance of two kinds of interferon γ release assays in the diagnosis of childhood pulmonary tuberculosis in China (with a high rate of bacillus Calmette-Guérin vaccination and a high incidence of tuberculosis), a total of 114 children with suspected pulmonary tuberculosis were recruited. Among the cases, 45 received QuantiFERON-Gold In-Tube (QFT-GIT) test while the other 69 were tested with T-SPOT.TB. The clinical information was collected for diagnostic classification. The sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) were compared between the two methods. The sensitivity of QFT-GIT in the diagnosis of childhood pulmonary tuberculosis was 86.4%, the specificity was 81.3%, PPV was 91.7%, and NPV was 76.5%. In contrast, the sensitivity of T-SPOT.TB was72.3%, the specificity was 93.7%, PPV was 97.1%, and NPV was 53.6%. The positive rates of two methods in the cases treated with glucocorticoids decreased significantly compared to those untreated. In conclusion, both QFT-GIT and T-SPOT.TB have high PPV in the diagnosis of childhood pulmonary tuberculosis since the rate of latent tuberculosis infection was low in children.
|
|
Received: 24 January 2014
Published: 25 June 2014
|
|
Corresponding Authors:
LU Shui-Hua
|
|
|
|
| [1] |
RUAN Qiao-Ling1, SHAO Ling-Yun1, WU Jing1, ZHANG Shu1, YU Sheng-Lei1, WANG Sen1, GAO Yan1, WANG Fei1, ZHANG Xi-Yan2, LIU Yuan-Yuan1, RAO Ying2, SHEN Yao-Jie1, ZHANG Ying1, ZHANG Wen-Hong1. Screening of tuberculosis infection in household contacts by interferon γ release assay and tuberculin skin test to predict active tuberculosis in China[J]. JOURNAL OF MICROBES AND INFECTIONS, 2015, 10(1): 28-33. |
|
|
|
|
