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Utilization of the ubiquitin system by viruses for survival and
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| XIONG Yao1; LIU Hong-Xia2; HUANG Qiao-Bing2 |
| 1 . First Clinical College of Medicine, Southern Medical University, Guangzhou 510515, China; 2 . School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China |
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Abstract As a complicated systemin eukaryocytes, the ubiquitin systemincludes mainly ubiquitin, 26S proteasome, enzyme E1, enzyme E2 , andenzyme E3. The ubiquitin-proteasome pathway is a major intracellular systemfor extralysosomal protein degradation and plays an important role in various cellular functional regulations. It has been found that many viruses could utilize the ubiquitin systemf or their own survival and reproduction by down-regulating surface immune molecules to escape the host immune responses, regulating viral transcription, inhibiting cellular apoptosis and helping with viral budding and release. Exploring the mechanisms underlying the use of the ubiquitin systemby viruses may provide an alternate view to understand the infection mechanisms and provide new targets for related antiviral therapeutics.
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Received: 07 September 2009
Published: 25 March 2010
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Corresponding Authors:
HUANG Qiao-Bing
E-mail: bing@fimmu.com
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2010, Vol. 5 
