外泌体在人类免疫缺陷病毒1型感染中的研究进展

邱勇1; 2; 马晶2; 曾毅1; 2

doi:10.3969/j.issn.1673-6184.2018.03.006

微生物与感染 >

2018 , Vol. 13 >Issue 3: 171 - 178

DOI: https://doi.org/10.3969/j.issn.1673-6184.2018.03.006

综述

外泌体在人类免疫缺陷病毒1型感染中的研究进展

邱勇1 ,
2 ,
马晶2 ,
曾毅1 ,
2

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1. 北京工业大学生命科学与生物工程学院，北京 100124；2. 中国疾病预防控制中心病毒病预防控制所传染病预防控制国家重点实验室，北京 102206

收稿日期: 2018-02-27

网络出版日期: 2018-01-01

基金资助

国家自然科学基金（81502974）

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Research advances in exosomes in human immunodeficiency virus type 1 infection

QIU Yong1 ,
2 ,
MA Jing2 ,
ZENG Yi1 ,
2

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1. College of Life Science and Bioengineering, Beijing University of Technology, Beijing 100124, China; 2. State Key Laboratory of Infectious Disease Prevention and Control，National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China

Received date: 2018-02-27

Online published: 2018-01-01

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摘要

外泌体(exosome)是动物细胞在生理或病理条件下分泌到胞外的内生性纳米微囊，在疾病发生机制和药物运输载体等研究领域成为新宠。近年来发现，外泌体在人类免疫缺陷病毒1型(human immunodeficiency virus type 1，HIV-1)感染者体内能转移病毒组分和病毒相关免疫分子，与HIV-1感染密切相关。本文以外泌体介导的HIV-1感染机制为重点，围绕外泌体与HIV-1感染的关系进行综述。

关键词： 外泌体; 人类免疫缺陷病毒1型; 感染; 传递

本文引用格式

邱勇1 , 2 , 马晶2 , 曾毅1 , 2 . 外泌体在人类免疫缺陷病毒1型感染中的研究进展[J]. 微生物与感染, 2018 , 13(3) : 171 -178 . DOI: 10.3969/j.issn.1673-6184.2018.03.006

Abstract

Exosomes are endogenous nanoparticles secreted by cells in physiological or pathological state. It is a durably hot topic in research fields of pathology and drug carrier systems. In recent years, it has been found that exosomes can transfer viral components and virus-related immune molecules in human immunodeficiency virus type 1 (HIV-1) infection. The mechanisms of exosome-mediated HIV-1 infection are reviewed in the present paper.

Key words： Exosome; Human immunodeficiency virus type 1; Infection; Delivery

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