肠道黏膜免疫与炎症小体的研究进展

黄佳铭1; 2; *; 杨冬雪1; *; 李晓曦1; 杨硕1

doi:10.3969/j.issn.1673-6184.2019.01.007

微生物与感染 >

2019 , Vol. 14 >Issue 2: 113 - 123

DOI: https://doi.org/10.3969/j.issn.1673-6184.2019.01.007

综述

肠道黏膜免疫与炎症小体的研究进展

黄佳铭1 ,
2 ,
* ,
杨冬雪1 ,
* ,
李晓曦1 ,
杨硕1

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1. 南京医科大学基础医学院免疫学系，南京 211100; 2. 南京医科大学基础医学院，江苏南京 211100

收稿日期: 2018-12-25

网络出版日期: 2019-04-25

基金资助

国家自然科学基金(81570499、81570499、91742116)

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Inflammasome and intestinal mucosal immunity

HUANG Jiaming1 ,
2 ,
* ,
YANG Dongxue1 ,
* ,
LI Xiaoxi1 ,
YANG Shuo1

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1. Department of Immunology, Basic Medical Sciences, Nanjing Medical University, Nanjing 211100, Jiangsu Province, China; 2. Basic Medical Sciences, Nanjing Medical University, Nanjing 211100, Jiangsu Province, China

Received date: 2018-12-25

Online published: 2019-04-25

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摘要

肠道是机体消化器官，为机体生命活动提供所需要的营养。肠道免疫系统有独特的功能，在抵抗潜在病原体侵入机体过程中发挥至关重要的作用。炎症小体是机体天然免疫系统中重要的蛋白复合体感受器，参与病原体引起的宿主防御反应，并在维持肠道免疫稳态中发挥关键作用。本文综述了肠道黏膜免疫系统及炎症小体在肠道免疫中的作用。

关键词： 肠道上皮细胞; 微生物; 肠道黏膜免疫; 炎症小体

本文引用格式

黄佳铭1 , 2 , * , 杨冬雪1 , * , 李晓曦1 , 杨硕1 . 肠道黏膜免疫与炎症小体的研究进展[J]. 微生物与感染, 2019 , 14(2) : 113 -123 . DOI: 10.3969/j.issn.1673-6184.2019.01.007

Abstract

Intestine is the largest digestive organ of human, providing essential nutrients for growth. The intestinal immune system has unique immunological characteristics and plays a key role in resisting environmental toxins and protecting against potential invading pathogens. Inflammasome is important protein complexes of innate immune system, participating in host defense response to pathogens and maintaining intestinal immune homeostasis. In this review, the intestinal mucosal immune system and the role of inflammasome in intestinal mucosal immunity are summarized.

Key words： Intestinal epithelial cell; Microbiota; Intestinal mucosal immunity; Inflammasome

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