鼠疫疫苗研究的现状与展望

魏东; 赵爱华; 王国治; 徐苗

doi:10.3969/j.issn.1673-6184.2020.03.001

微生物与感染 >

2020 , Vol. 15 >Issue 3: 135 - 142

DOI: https://doi.org/10.3969/j.issn.1673-6184.2020.03.001

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鼠疫疫苗研究的现状与展望

魏东 ,
赵爱华 ,
王国治 ,
徐苗

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中国食品药品检定研究院结核病和过敏原产品室，卫生部生物技术产品检定方法及其标准化重点实验室，北京 102629

收稿日期: 2020-02-01

网络出版日期: 2020-06-25

基金资助

重大新药创制国家科技重大专项（2014ZX09304311-002）

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Current research and prospects of plague vaccine

WEI Dong ,
ZHAO Aihua ,
WANG Guozhi ,
XU Miao

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Division of Tuberculosis Vaccines and Allergen, National Institutes for Food and Drug Control, Key Laboratory of the Ministry of Health for Research on Quality and Standardization of Biotech Products, Beijing 102629, China

Received date: 2020-02-01

Online published: 2020-06-25

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摘要

鼠疫（Plague）是由鼠疫耶尔森菌(Yersina pestis，Y. pestis)（简称鼠疫菌）引起的一种烈性传染病，属甲类传染病，具有高度传染性和致病性。在过去的鼠疫大流行中近2亿感染者死亡。疫苗接种是疾病预防控制的重要方法。现就鼠疫疫苗的研究进展作一综述，为新疫苗的研制提供参考。

关键词： 鼠疫; 鼠疫耶尔森菌; 疫苗; 抗原

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魏东 , 赵爱华 , 王国治 , 徐苗 . 鼠疫疫苗研究的现状与展望[J]. 微生物与感染, 2020 , 15(3) : 135 -142 . DOI: 10.3969/j.issn.1673-6184.2020.03.001

Abstract

Plague is a category A infectious disease, which is highly infectious and pathogenic. Three great plague pandemics resulted in nearly 200 million deaths in human history. Prophylactic vaccination is an important method of disease prevention and control. In this review, we summarize the current advances in research and development of plague vaccines and provide a reference for the study of new vaccines.

Key words： Plague; Yersinia pestis; Vaccine; Antigens

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