Epstein-Barr virus (EBV) is a lymphatic follicular virus, and its infection is a very common concern for human health. The present paper aims to investigate the clinical feature and consequences of EBV-associated lymphoma patients. The clinical data of 49 patients who were diagnosed with lymphoma with EBV infection from January 2013 to December 2016 were retrospectively analyzed. Among the 49 EBV-associated lymphoma patients, 18 with B cell lymphoma and 31 with T/NK cell lymphoma. Among the relevant laboratory indicators, inter-group statistical differences existed in white blood cell count, platelet count, alanine aminotransferase level, aspartate aminotransferase level, lactate dehydrogenase level, ferritin level, fibrinogen level, erythrocyte sedimentation rate and C-reactive protein level. The median follow-up period was 5.0 months. The results showed that compared with EBV-associated B cell lymphoma patients, EBV-associated T/NK cell lymphoma patients had more severe liver function damage, more frequency of hemophagocytic syndrome, and shorter survival period. But there was no significant difference in survival period between the two groups (P>0.05). The 1-month, 6-month, 1-year and 3-year overall survival rates were 84.4%, 59.8%, 53.2% and 40.3%, respectively.