Preliminary study on the role of membrane transport molecules ABCC3 and SLC7A7 in enterovirus A71 infection EV72 infection

WANG Jiaqi1; HU Xuce2; LIU Yangang1; CHEN Shenglin3; REN Hao1; QI Zhongtian1

doi:10.3969/j.issn.1673-6184.2021.01.002

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Journal of Microbes and Infections ›› 2021, Vol. 16 ›› Issue (1) : 10-18. DOI: 10.3969/j.issn.1673-6184.2021.01.002

Preliminary study on the role of membrane transport molecules ABCC3 and SLC7A7 in enterovirus A71 infection EV72 infection

WANG Jiaqi¹, HU Xuce², LIU Yangang¹, CHEN Shenglin³, REN Hao¹, QI Zhongtian¹

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Abstract

Enterovirus A71 (EV-A71) is one of the main pathogens causing hand-foot-mouth disease (HFMD). There are no specific and effective antiviral drugs for the treatment of HFMD. Studies have shown that cell membrane transport molecules are involved in virus invasion, replication and the release of infectious virus particles. In order to find the host factors that can effectively inhibit EV-A71 infection, human colon cancer cells (Caco-2) were used as target cells, and RNA interference was used to downregulate the expression of transport-related membrane proteins. The data showed that ATP-binding cassette transport subfamily C member 3 (ABCC3) and solute carrier family 7 member 7 (SLC7A7) played important roles in EV-A71 infection in Caco-2 cells, which provided potential targets for the prevention and treatment of EV-A71 infection.

Key words

ATP-binding cassette transporter subfamily C member 3 / Solute carrier family 7 member 7 / Human colon cancer cell (Caco-2) / RNA interference / Enterovirus A71

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WANG Jiaqi1, HU Xuce2, LIU Yangang1, CHEN Shenglin3, REN Hao1, QI Zhongtian1. Preliminary study on the role of membrane transport molecules ABCC3 and SLC7A7 in enterovirus A71 infection EV72 infection[J]. Journal of Microbes and Infections. 2021, 16(1): 10-18 https://doi.org/10.3969/j.issn.1673-6184.2021.01.002