As the research progresses on intestinal flora, more and more evidences show that the imbalance of intestinal flora is closely related to the occurrence and progression of many chronic diseases. Probiotic treatment has become a worldwide hotspot, and Akkermansia muciniphlia (A. muciniphila), a common colonizer in the mucous layer of human intestines, has gradually been regarded as a promising candidate for the next-generation probiotics. The present paper summarizes the ameliorating effects of A. muciniphila on chronic diseases and the possible mechanisms, providing a new idea for the treatment of diseases.