Recently, therapeutic monoclonal antibodies have become the focus of interest for basic medicine researchers, clinicians and industries. Therapeutic antibodies have been used to block the “check points” in immune responses in tumor patients and have shown their effectiveness. Currently, with the emergence of antibiotic-resistant microbial strains, global threats on acute emerging infections, as well as difficult-to-treat persistent infections, therapeutic antibodies for microbes are also under development. This review introduces the progress on therapeutic antibodies in microbial infections, and the perspectives of this field are also presented.