Vaccine development for syphilis

ZHENG Kang1; LIU Anyuan1; 2; WU Yimou1

doi:10.3969/j.issn.1673-6184.2019.03.007

Journal of Microbes and Infections >

2019 , Vol. 14 >Issue 3: 180 - 184

DOI: https://doi.org/10.3969/j.issn.1673-6184.2019.03.007

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Vaccine development for syphilis

ZHENG Kang1 ,
LIU Anyuan1 ,
2 ,
WU Yimou1

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1. Institution of Pathogenic Biology, Medical College, University of South China, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Hengyang, 421001, China; 2. The Second Affiliated Hospital of University of South China, Hengyang 421001, China

Received date: 2019-04-22

Online published: 2019-06-25

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Abstract

Syphilis is a sexually transmitted infection caused by Treponema pallidum subsp. Pallidum (T. pallidum), Over 90% of syphilis cases occur in low- and middle-income countries. Studies indicated that elimination of T. pallidum requires enhanced public health screening, treatment and vaccination. This article provides an overview of the need for development of a syphilis vaccine, summarizes the information and delivery system and candidate antigens in development, and analyzes the development strategies for T. pallidum vaccine.

Key words： Treponema pallidum subsp. pallidum; Vccine; Candidate antigens; Delivery system; Development strategy 　

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ZHENG Kang1 , LIU Anyuan1 , 2 , WU Yimou1 . Vaccine development for syphilis[J]. Journal of Microbes and Infections, 2019 , 14(3) : 180 -184 . DOI: 10.3969/j.issn.1673-6184.2019.03.007

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