The &ldquo;intestinal mechanism&rdquo; of anti-diabetes drugs

FENG Yuwei1; ZHANG Feng2; 3; 1; WANG Xuesong3; 4; 1; XIA Yanping2; 3; HUA Jiao5; 1; CAO Hong1; 2; 3; 6

doi:10.3969/j.issn.1673-6184.2021.01.009

Journal of Microbes and Infections >

2021 , Vol. 16 >Issue 1: 63 - 70

DOI: https://doi.org/10.3969/j.issn.1673-6184.2021.01.009

Review

The “intestinal mechanism” of anti-diabetes drugs

FENG Yuwei1 ,
ZHANG Feng2 ,
3 ,
1 ,
WANG Xuesong3 ,
4 ,
1 ,
XIA Yanping2 ,
3 ,
HUA Jiao5 ,
1 ,
CAO Hong1 ,
2 ,
3 ,
6

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1. Wuxi School of Medicine, Jiangnan University, Wuxi 214122, Jiangsu Province, China; 2. Nutritional Department, Affiliated Hospital of Jiangnan University, Wuxi 214122, Jiangsu Province, China; 3. Clinical Assessment Center of Functional Food, Affiliated Hospital of Jiangnan University, Wuxi 214122, Jiangsu Province, China; 4. Department of Orthopedics, Affiliated Hospital of Jiangnan University, Wuxi 214122, Jiangsu Province, China; 5. Hospital Infection－Control Dep, Affiliated Hospital of Jiangnan University, Wuxi 214122, Jiangsu Province, China; 6. Department of Endocrinology, Affiliated Hospital of Jiangnan University, Wuxi 214122, Jiangsu Province, China

Received date: 2020-03-05

Online published: 2021-02-25

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Abstract

Diabetes is one of the most serious public health problems in China. Recently, growing evidence demonstrated that gut microbiota are closely involved in the onset and development of type 2 diabetes. Studies also indicated that anti-diabetic drugs can achieve the effect of lowering blood glucose by modulating gut microbiota to carry out “molecular dialogue” with the host. This paper summarized the recent publications related to the intestinal mechanism of anti-diabetic drugs.

Key words： Diabetes mellitus; Gut microbiota; Anti-diabetic drug; Glucolipid metabolism

Cite this article

FENG Yuwei1 , ZHANG Feng2 , 3 , 1 , WANG Xuesong3 , 4 , 1 , XIA Yanping2 , 3 , HUA Jiao5 , 1 , CAO Hong1 , 2 , 3 , 6 . The “intestinal mechanism” of anti-diabetes drugs[J]. Journal of Microbes and Infections, 2021 , 16(1) : 63 -70 . DOI: 10.3969/j.issn.1673-6184.2021.01.009

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