Cryptococcal cell morphology and Pathogenic mechanism
PAN Bo; CHEN Min; PAN Wei-Hua; LIAO Wan-Qing
Institute of Dermatology and Mycoses, Shanghai Key Laboratory of Medical Molecular Mycology, PLA Key Laboratory of Fungal Diseases, Department of Dermatology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China
Abstract：The interaction between fungal pathogens and host frequently results in morphological changes, such as hyphae formation. It is important for fungus to adapt and survive the harsh environment of host. Cryptococcus is an encapsulated yeast species that can cause cryptococcosis. Natural infection begins with inhalation of cryptococcal spores. The enlargement of capsule and formation of giant cells may be the defence strategy that allows Cryptococcus to resist and evade host immune response. Understanding the association between morphological changes and pathogenicity can help us to improve clinical diagnosis and therapy of this disease.
