Investigation and follow-up of tuberculosis infection among close contacts of active tuberculosis
LIU Yuanyuan1, QIN Xiaowen2, CHEN Huaxin2, YU Zhiming2, OU Qinfang2, LIU Qianqian1, XU Yuzhen1, YANG Qinluan1, ZHANG Bingyan1, GAO Yan1, ZHANG Wenhong1, SHAO Lingyun1
1. Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai 200040, China; 2. Department of Tuberculosis, Wuxi No.5 People’s Hospital, Wuxi 214007, Jiangsu Province, China
Abstract：This paper screened and followed up close contacts of active pulmonary tuberculosis to understand the latent infection and morbidity of close contacts and analyze related factors. It retrospectively analyzed the clinical data of patients with active pulmonary tuberculosis hospitalized in the tuberculosis ward of Wuxi No.5 People’s Hospital from March 2012 to August 2019, and analyzed and followed up the close contacts who had conducted the interferon-γ release assay (IGRA). A total of 39 active pulmonary tuberculosis patients under initial treatment and 74 close contacts were included in the analysis. Of all the 74 close contacts, 27 contacts were IGRA positive (36.5%) and 47 contacts were IGRA negative (63.5%). None of the 27 IGRA-positive close contacts progressed to active tuberculosis, but the differences between the two groups in terms of smoking (3/27 vs 0/47, P＝0.045), contact time with tuberculosis patients >5 h/d (22/27 vs 23 /47, P＝0.007), living in the same house (23/27 vs 20/47, P＝0.001) were statistically significant. Active tuberculosis patients corresponding to IGRA-positive close contacts and those corresponding to IGRA-negative close contacts were further compared, respectively, which found that the active TB patients corresponding to the IGRA positive group had more sputum smear tuberculosis bacteria load than that of the IGRA negative group (P＝0.019). Multivariate analysis showed that the amount of tuberculosis bacteria in sputum smear of tuberculosis patients was a significant factor influencing IGRA results of their close contacts. Close contacts of active pulmonary tuberculosis with higher sputum tuberculosis load are more likely to be IGRA positive.
刘袁媛1，*，秦小雯2，*，陈华昕2，于志明2，欧勤芳2，刘倩倩1，许毓贞1，杨清銮1，张冰琰1，高岩1，张文宏1，邵凌云1. 活动性肺结核密切接触者结核感染情况及随访分析[J]. 微生物与感染, 2022, 17(6): 360-365.
LIU Yuanyuan1, QIN Xiaowen2, CHEN Huaxin2, YU Zhiming2, OU Qinfang2, LIU Qianqian1, XU Yuzhen1, YANG Qinluan1, ZHANG Bingyan1, GAO Yan1, ZHANG Wenhong1, SHAO Lingyun1. Investigation and follow-up of tuberculosis infection among close contacts of active tuberculosis. JOURNAL OF MICROBES AND INFECTIONS, 2022, 17(6): 360-365.
2022, Vol. 17 
