Distribution and drug sensitivity of otitis pathogens of children in Nanning
LIU Minxue, LIANG Jiahui, HUANG Liying, CEN Zhenjiao, WANG Shuangjie, YAN Chenglan
Department of Laboratory Medicine in the Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Nanning 530000, Guangxi Zhuang Autonomous Region, China
Abstract：The purpose of the current study is to analyze the pathogens of otitis in children and its drug sensitivity for references of clinical empirical medication. In this retrospective study, we analyzed ear secretion culture data of the children with otitis in the Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region from January 2019 to December 2021. We calculated the constituent ratio of the positive bacteria and fungi, then analyzed the drug sensitivity of the major Gram-positive bacteria, Gram-negative bacteria and candida. The results demonstrated that, of all the 918 ear secretion samples, 623 were positive culture. 438 (70.30%) were bacteria positive, and 164 (26.32%) were fungi positive, while 21 (3.37%) were both bacteria and fungi positive. Staphylococcus aureus and Streptococcus pneumoniae were the major gram-positive bacteria, and Pseudomonas aeruginosa and Haemophilus influenzae were the major gram-negative bacteria. The most common yeast fungi were Candida parapsilosis and Candida albicans, and the top two mould were Aspergillus flavus and Aspergillus niger. As results of drug sensitivity test of main gram-positive bacteria, Staphylococcus aureus were sensitive to vancomycin, linezolid, aminoglycosides and quinolones, but showed high resistance to penicillin and macrolides. However, most Streptococcus pneumoniae were sensitive to penicillin, vancomycin, levofloxacin and amoxicillin-clavulanic acid, but were highly resistant to macrolides and the second generation cephalosporins. In terms of major gram-negative bacteria, Pseudomonas aeruginosa were widely sensitive to penicillins, cephalosporins, quinolones and carbapenems agents. And, all Haemophilus influenzae in the study were sensitive to amoxicillin-clavulanic and ofloxacin, but a part of strains were resistant to sulfamethoxazole, ampicillin and the second generation cephalosporins. Antifungal drug sensitivity results showed that all isolated Candida parapsilosis and a large part of Candida albicans were sensitive to triazole drugs. It concludes that the top three pathogenic bacteria of otitis in children are Staphylococcus aureus, Streptococcus pneumoniae and Pseudomonas aeruginosa. In terms of pathogenic fungi, the major yeast and mould are Candida parapsilosis and Aspergillus flavus, respectively. Clinicians could empirically administrate antibiotics or antifungal agents referring to our study results before getting culture and drug sensitivity reports.
刘敏雪，梁嘉慧，黄丽英，岑贞娇，王双杰，颜程岚. 南宁地区儿童耳炎病原菌分布特征及药敏分析[J]. 微生物与感染, 2022, 17(6): 366-373.
LIU Minxue, LIANG Jiahui, HUANG Liying, CEN Zhenjiao, WANG Shuangjie, YAN Chenglan. Distribution and drug sensitivity of otitis pathogens of children in Nanning. JOURNAL OF MICROBES AND INFECTIONS, 2022, 17(6): 366-373.
2022, Vol. 17 
