Research progress on vaginal microbiome and its relationship with human papillomavirus infection and cervical disease
JI Lingyun1，2，WU Jing3，ZHOU Yang3，WU Wenjuan1
1. Department of Laboratory Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200123, China; 2. School of Life Sciences, Fudan University, Shanghai 200438, China; 3. Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai 200040, China
Abstract：The human vaginal microbiota (VMB), which plays a vital role in maintaining health and homeostasis, exhibits low diversity compared to the microbiomes of other organs. Cervical cancer (CC) is a common malignancy in women and has been shown to be highly associated with persistent infection with high-risk human papillomavirus (HPV). VMB is associated with human papillomavirus infection and cervical lesions, and may play a positive role in the progression of HPV infection and cervical intraepithelial neoplasia (CIN). On the one hand, lactobacillus can reduce the permeability of cervical cells, and reduce inflammatory response, inhibit the growth of cervical cancer cells, but the bacterias enhancing the diversity of VMB can express virulence and attachment genes, which cause damage to cervix and epithelial cells, causing HPV infection and high-grade disease states; On the other hand, HPV-associated E7 oncoprotein can reduce the secretion of defense peptides which are conducive to the growth of lactobacillus through NF-β-κB and Wnt/β-catenin signaling pathways, resulting in an increase in vaginal pH, which further facilitates the growth of vaginal pathogenic bacteria, and ultimately leads to structural changes of VMB. This review focuses on the relationship between the vaginal microbiome, persistent HPV infection and cervical dysplasia and the factors that mediate these relationships, which will help to find new targets for VMB-related diseases.
纪凌云1, 2，吴晶3，周旸3，吴文娟1. 阴道微生物组与HPV感染和宫颈病变的相关性研究进展[J]. 微生物与感染, 2023, 18(4): 251-256.
JI Lingyun1，2，WU Jing3，ZHOU Yang3，WU Wenjuan1. Research progress on vaginal microbiome and its relationship with human papillomavirus infection and cervical disease. JOURNAL OF MICROBES AND INFECTIONS, 2023, 18(4): 251-256.
2023, Vol. 18 
