Correlation analysis between human papillomavirus 16 infection and cervical diseases in Chengdu
JIAN Jie1, LIANG Kairu2, YU Shaolan5, WANG Qingqing5, YI Xiaolian5, ZHAO Qingping4, SHI Yanyan3, XIE Chengbin3, XIA Chun4, GAO Lili4, LUO Na4, ZUO Fengqiong6, LI Wanyi1
1. Department of Microbiology, West China of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, China; 2. Department of Women’s Health Care, Maternal and Child Health Care Hospital of Sichuan Province, Chengdu 610031, China; 3. Department of Laboratory, Maternal and Child Health Care Hospital of Sichuan Province, Chengdu 610031, China; 4. Department of Gynaecology, Maternal and Child Health Care Hospital of Sichuan Province, Chengdu 610031, China; 5. Department of Pathology, Maternal and Child Health Care Hospital of Sichuan Province, Chengdu 610031, China; 6. Department of Immunology, West China of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, China
Abstract：The present paper aims to investigate the relationship between human papillomavirus 16 (HPV16) infection in cervical diseases, and to provide scientific basis for prevention and treatment of cervical cancer. The proportion of HPV16 in different cervical diseases, the prevalence of HPV16 infection in the patients with cervical intraepithelial neoplasia (CIN) Ⅱ and higher diseases in different age groups, and the prevalence of simple and multiple infections of HPV were analyzed. A total of 1 057 patients infected with HPV were selected, and subjected to sub-typing for HPVs. The results revealed that 352 patients were HPV16 positive and the proportion of HPV16 detection was the highest in CIN Ⅲ group. The proportion of HPV16 positive was significantly different among varied cervical diseases (P<0.05) and it gradually increased along with the increased disease grade (P<0.05). There were significant differences in the prevalence of HPV16 infection in the patients with CIN Ⅱ and higher diseases among different age groups (P<0.05). The prevalence increased with the increased age (P<0.05). The prevalence of HPV16 infection in the patients with CIN Ⅱ and higher diseases was significant different between HPV simple and multiple infections (P<0.05). With types of HPV increasing, the prevalence showed a tendency of increase. The research indicates that there is certain relationship between HPV16 infection and high-grade cervical lesions. The older persons infected with HPV16 have the greater risks for cervical cancer. Taking the persistent infection of HPV16 into account, timely diagnosis and treatment for HPV infection could reduce the occurrence of high-grade CIN and cervical cancer.
简洁1，梁开如2，余绍兰5，王青青5，易晓恋5，赵清平4，石艳艳3，谢成彬3，夏春4，高丽丽4，罗娜4，左凤琼6，李婉宜1. 成都市人乳头瘤病毒16型感染与宫颈病变的相关性分析[J]. 微生物与感染, 2017, 12(1): 35-39.
JIAN Jie1, LIANG Kairu2, YU Shaolan5, WANG Qingqing5, YI Xiaolian5, ZHAO Qingping4, SHI Yanyan3, XIE Chengbin3, XIA Chun4, GAO Lili4, LUO Na4, ZUO Fengqiong6, LI Wanyi1. Correlation analysis between human papillomavirus 16 infection and cervical diseases in Chengdu. JOURNAL OF MICROBES AND INFECTIONS, 2017, 12(1): 35-39.
2017, Vol. 12 
