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BDSF抑制临床白假丝酵母菌丝生长的效果分析
徐振华1,廖勇2,李梦3,廖万清3,翁丽星1,4,汪联辉5
1. 复旦大学生命科学学院微生物学和微生物工程系,上海 200433;2. 北京军区总医院皮肤科,北京100700;3. 第二军医大学长征医院皮肤科,上海200003;4. 南京邮电大学地理与生物信息学院,南京 210046;5. 南京邮电大学信息材料与纳米技术研究院,南京 210046
Inhibitory effect of BDSF on hyphal growth of clinical Candida albicans
XU Zhen-Hua1, LIAO Yong2, LI Meng3, Liao Wan-Qing3, WENG Li-Xing1,4, WANG Lian-Hui 5
1. Department of Microbiology and Microbial Engineering, School of Life Science, Fudan University, Shanghai 200433, China;.2. Department of Dermatology, General Hospital of Beijing Military Command, Beijing 100700, China; 3. Shanghai Key Laboratory of Molecular Mycology & PLA Key Laboratory of Fungal Diseases, Changzheng Hospital, The Second Military Medical University, Shanghai 200003, China; 4. College of Geography and Biological Information, Nanjing University of Posts and Telecommunications, Nanjing 210046, China; 5. Institute of Advanced Materials, Nanjing University of Posts and Telecommunications, Nanjing 210046, China
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摘要: 随着现代医学的发展,抗真菌药物广泛应用,白假丝酵母(又称白念珠菌)耐药现象日益严重。由酵母相转变为菌丝相是白念珠菌致病的一个必要过程,抑制菌丝形成可控制其感染。细菌群体感应信号分子BDSF(顺十二碳­-2-­烯酸)可抑制这一形态的转变,从而抑制白念珠菌的致病力。本研究检测BDSF对60株白念珠菌临床菌株的抑菌丝效果,同时测定这60株临床菌株对氟康唑的敏感度。结果显示,60株临床菌株中8株(13.3%)对氟康唑耐药,最低抑菌浓度(MIC)≥64 μg/ml,而BDSF对耐与不耐氟康唑的临床菌株均能高效抑制菌丝生长。结果表明,BDSF可作为临床治疗白念珠菌感染的新型候选药物,值得进一步研究。

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徐振华1
廖勇2
李梦3
廖万清3
翁丽星1
4
汪联辉5
关键词 白念珠菌BDSF氟康唑    
Abstract:The drug resistance of Candida albicans (C. albicans), resulted from gradual application of advanced medical treatments and the widespread use of antifungals, has become a severe problem in clinic. C. albicans is one of the major opportunistic human fungal pathogens. The transition from yeast to hypha is a necessary process in its pathogenic activity, and inhibiting the hypha formation can decrease its infective ability. Quorum sensing signal BDSF (short­-chain fatty acid) from Burkholderiacenocepacia can inhibit the yeast­to­hypha transition and hinder the virulence of C. albicans. The drug susceptibility of 60 C.albicans clinical isolates to fluconazole and BDSF were determined respectively. The results showed there were 8 strains (13.3%) resistant to fluconazole, with the minimum inhibitory concentration (MIC) ≥64 μg/ml, but BDSF showed efficiently inhibitory effect on all the clinical isolates no matter the isolates were resistant to fluconazole or not. The results suggest that BDSF might be a new clinical option to treat C. albicans infection.

Key wordsCandida albicans    BDSF    Fluconazole
基金资助:国家自然科学基金(81273409)

通讯作者: 翁丽星   
引用本文:   
徐振华1,廖勇2,李梦3,廖万清3,翁丽星1,4,汪联辉5. BDSF抑制临床白假丝酵母菌丝生长的效果分析[J]. 微生物与感染, 2015, 10(4): 247-251.
XU Zhen-Hua1, LIAO Yong2, LI Meng3, Liao Wan-Qing3, WENG Li-Xing1,4, WANG Lian-Hui 5. Inhibitory effect of BDSF on hyphal growth of clinical Candida albicans. JOURNAL OF MICROBES AND INFECTIONS, 2015, 10(4): 247-251.
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