Inhibitory effect of BDSF on hyphal growth of clinical Candida albicans
XU Zhen-Hua1, LIAO Yong2, LI Meng3, Liao Wan-Qing3, WENG Li-Xing1,4, WANG Lian-Hui 5
1. Department of Microbiology and Microbial Engineering, School of Life Science, Fudan University, Shanghai 200433, China;.2. Department of Dermatology, General Hospital of Beijing Military Command, Beijing 100700, China; 3. Shanghai Key Laboratory of Molecular Mycology & PLA Key Laboratory of Fungal Diseases, Changzheng Hospital, The Second Military Medical University, Shanghai 200003, China; 4. College of Geography and Biological Information, Nanjing University of Posts and Telecommunications, Nanjing 210046, China; 5. Institute of Advanced Materials, Nanjing University of Posts and Telecommunications, Nanjing 210046, China
Abstract：The drug resistance of Candida albicans (C. albicans), resulted from gradual application of advanced medical treatments and the widespread use of antifungals, has become a severe problem in clinic. C. albicans is one of the major opportunistic human fungal pathogens. The transition from yeast to hypha is a necessary process in its pathogenic activity, and inhibiting the hypha formation can decrease its infective ability. Quorum sensing signal BDSF (short-chain fatty acid) from Burkholderiacenocepacia can inhibit the yeasttohypha transition and hinder the virulence of C. albicans. The drug susceptibility of 60 C.albicans clinical isolates to fluconazole and BDSF were determined respectively. The results showed there were 8 strains (13.3%) resistant to fluconazole, with the minimum inhibitory concentration (MIC) ≥64 μg/ml, but BDSF showed efficiently inhibitory effect on all the clinical isolates no matter the isolates were resistant to fluconazole or not. The results suggest that BDSF might be a new clinical option to treat C. albicans infection.