BDSF differently affects yeast and hyphae Candida albicans
ZHOU A-Feng1; Wang Lian-Hui2; WENG Li-Xing1
1.Department of Microbiology and Microbial Engineering, School of Life Sciences, Fudan University, Shanghai 200433, China; 2. Institute of Advanced Materials, Nanjing University of Posts and Telecommunications, Nanjing, Jiangsu, 210046, China
Abstract：Candida albicans (C. albicans) is a very important opportunistic human pathogenic fungus. It is a harmless symbiotic fungus that inhabits various niches of healthy individuals. However, in the immunocompromised population, C. albicans can cause infection and even C. albicans candidiasis, which can range from superficial mucous membrane infection to life-threatening systemic disease. The state change of hypha from yeast form is a extremely important pathogenic factor. BDSF is a short-chain fatty acid molecule, secreted by the Burkholderia cenocepacia. When BDSF was added to yeast state at 30 μmol/L, it strongly inhibited the mycelial growth of C. albicans, so that yeast C. albicans could not be achieved to the change of the hyphal state; when at the concentration of 30 μmol/L and 60 μmol/L, BDSF did not inhibit the further growth and branching hyphae, but with the growth of mycelium branches the new-born branches of the mycelium were constantly changed into yeast state; when at the concentration of 120 μmol/L, BDSF almost completely inhibited the mycelial growth and branching. It’s suggested that BDSF not only strongly inhibits the hypha growth from yeast state but also forcefully promotes the transition from new-born hypha to yeast state.
