Toxin-antitoxin systems and biofilm of Mycobacterium tuberculosis
ZHAO Jili1,*, LIU Wei1,*, WANG Tiepeng2, YUAN Li1
1. Department of Pathogenic Biology and Immunology, Medical School of Shihezi University, Shihezi 832000, China; 2. Department of Biochemistry, Medical School of Shihezi University, Shihezi 832000, China
Abstract：Mycobacterium tuberculosis (M. tuberculosis) is causative pathogen of tuberculosis, and could induce long-term asymptomatic infection, known as latent tuberculosis infection (LTBI), in which the bacteria are thought to persist in a dormant state. It is reported that there are pairs of toxin-antitoxin systems (TASs) in chromosomes of M. tuberculosis. Some TASs play roles in the latent infection because they could not only regulate the bacterial growth, but also induce the bacteria to enter dormant state. Some TASs are suggested to be involved in the biofilm formation and stress reaction, but how they regulate biofilm formation has not yet been elucidated. M. tuberculosis in biofilm is resistant to many drugs and host immune protections. M. tuberculosis in dormant state is usually multidrug-resistant. These issues bring challenges for the treatment of tuberculosis. This review focuses on the research progress on TAS and biofilm formation of M. tuberculosis, as well as the effect of anti-tuberculosis drugs on biofilm formation.
赵继利1*，刘微1*，王铁鹏2，袁俐1. 结核分枝杆菌毒素-抗毒素系统与生物膜[J]. 微生物与感染, 2017, 12(6): 375-380.
ZHAO Jili1,*, LIU Wei1,*, WANG Tiepeng2, YUAN Li1. Toxin-antitoxin systems and biofilm of Mycobacterium tuberculosis . JOURNAL OF MICROBES AND INFECTIONS, 2017, 12(6): 375-380.