Gene polymorphisms of interleukin 22 and their interaction with susceptibility to tuberculosis in Chinese population
XIONG Kunlong1, ZHANG Wenhong2, WANG Feifei1, CHENG Xunjia1
1. Department of Medical Microbiology and Parasitology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China; 2. Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai 200040, China
Abstract：To investigate a potential impact of interleukin 22 (IL-22) gene polymorphisms on susceptibility to pulmonary tuberculosis (PTB) in a Chinese population, a case-control study was conducted in PTB cases (n＝453), latent tuberculosis infection (LTBI) cases (n＝109) and healthy controls (HCs) (n＝264). Genetic polymorphisms of rs1179249, rs2227491, rs17224704, rs2227478 were analyzed by using SNPscan™ technique. The genetic frequencies of four single nucleotide polymorphisms (SNPs) met Hardy-Weinberg equilibrium. In the population older than 55, the frequency of genotype TA of rs17224704 SNP was significantly higher in healthy control group than that in PTB group (P＝0.047 9，OR＝0.365，95% CI＝0.135－0.991). The frequency of genotype AA of rs17224704 SNP was significantly lower in LTBI group than that in PTB group (P＝0.027 6). The frequency of genotype TA of rs17224704 SNP was significantly higher in LTBI group than that in PTB group (P＝0.007 37, OR＝0.213，95% CI＝0.069－0.660). The frequency of allele T of rs17224704 SNP was significantly higher in healthy control group and LTBI group than that in PTB group (P＝0.026 9, OR＝0.388, 95% CI＝0.167－0.897; P＝0.025 0, OR＝0.322, 95% CI＝0.119－0.867). The results suggest that allele T of rs17224704 gene in Chinese Han population from Chongqing is probably associated with protection against tuberculosis.
熊坤龙 1，张文宏2，王菲菲1，程训佳1. IL-22基因多态性与中国人群肺结核易感性的相关性研究[J]. 微生物与感染, 2018, 13(2): 70-76.
XIONG Kunlong1, ZHANG Wenhong2, WANG Feifei1, CHENG Xunjia1. Gene polymorphisms of interleukin 22 and their interaction with susceptibility to tuberculosis in Chinese population. JOURNAL OF MICROBES AND INFECTIONS, 2018, 13(2): 70-76.
2018, Vol. 13 
