近年来，由于抗生素的不合理及广泛使用，全球多重耐药菌和广泛耐药菌不断出现。关于细菌耐药机制中外排泵及生物膜形成的研究越来越受关注。研究发现，外排泵与生物膜形成有密切联系，不同细菌的不同外排泵对生物膜形成的影响各异，而生物膜形成又影响外排泵基因表达。本文就细菌耐多药外排泵的研究进展进行综述。

Multidrug-resistant bacteria and pan-drug resistant bacteria are major clinical concerns associated with misuse and abuse of antibiotics. The multidrug efflux pumps and biofilm formation, two mechanisms of drug resistance, are catching more attentions recently. Studies demonstrated that some efflux pumps in different bacteria influence biofilm formation, which in turn changes the gene expression of efflux pumps, indicating a possible interaction between multidrug efflux pumps and biofilm formation.