Abstract：To summarize the clinical features of Elizabethkingia meningoseptica(EM) meningitis in infants. Case histories (including clinical features, laboratory examination, treatment, prognosis) of 3 EM meningitis in infants who were hospitalized at Boai Hospital from January 1, 2010 to December 31, 2020 were analyzed retrospectively. 3 cases were diagnosed by a positive cerebrospinal fluid culture of EM. 3 cases were full-term natural delivery, 2 cases were neonatal onset, 1 case was 35 days onset, no risk factors were found before onset. Fever was the main symptom, no convulsions and meningeal irritation sign. Peripheral blood leucocyte count, C-reactive protein and procalcitonin of 3 cases were increased. Pan's test of cerebrospinal fluid (CSF) was positive, the nucleated cell count in CSF was elevated; the protein level was substantially elevated; the glucose level was decreased. Representation of CT or MRI examination showed meningeal enhancement, without brain parenchyma involvement. The results of drug sensitivity of 3 strains showed high consistency. Drug sensitivity test showed that bacteria were all sensitive to ciprofloxacin, piperacillin/tazobactam, levofloxacin and cotrimoxazole. 2 cases were treated with ciprofloxacin, 1 case was treated with meropenem combined with vancomycin, one case was cured, and two cases were discharged after clinical improvement. Telephone follow-up showed that the general condition of 3 cases was normal. EM meningitis mainly occurs in the neonatal stage, fever was the main manifestation. EM was resistant to the antimicrobials which had been commonly used in the department of pediatrics in vitro and sensitive to quinolones.
任伟，刘莉，谢广清，龙晓玲. 3例婴儿脑膜炎败血伊丽莎白菌脑膜炎临床分析[J]. 微生物与感染, 2021, 16(5): 339-342.
REN Wei, LIU Li, Xie Guangqing, LONG Xiaoling. Clinical features of 3 cases of infants with Elizabethkingia meningoseptica meningitis. JOURNAL OF MICROBES AND INFECTIONS, 2021, 16(5): 339-342.
2021, Vol. 16 
