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Research advance on Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis |
LI-Jun, ZHU Qi-Rong |
Children’s Hospital of Fudan University, Shanghai 201102, China |
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Abstract Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis (EBV-HLH) is a rapidly progressive disease with a high rate of mortality. In the patients with EBV-HLH, hypercytokinemia plays a major pathogenetic middle mechanism. The clinical manifestations were various and its diagnosis should meet HLH 2004 criteria as well as EBV-positive. In terms of treatment, the combination of dexamethasone, etoposide and cyclosporin A is the first choice. If they do not work,hematopoietic stem cell transplantation can be done. The recent progress on diagnosis and treatment of EBV-HLH is reviewed in the present paper.
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Received: 24 January 2014
Published: 25 September 2014
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Corresponding Authors:
ZHU Qi-Rong
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