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Regulatory role of small RNA in intracellular bacterial growth, virulence and iron level |
WU Zheng, LI Wenjing, LI Aimei, FU Yingmei, ZHANG Fengmin |
Department of Microbiology, Harbin Medical University, Wu Lien-Teh Institute, The Heilongjiang Key Laboratory of Immunity and Infection, The Key Laboratory of Pathogenic Biology, Heilongjiang Higher Education Institutions, Harbin 150081, China |
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Abstract Small RNA (sRNA) is a class of non-coding RNA of 50-500 bases with a regulatory function on transcription, translation and mRNA stability. Bacterial sRNAs have been implicated in gene expression, cellular proliferation, virulence and adaptation to environmental conditions. The role of sRNAs in intracellular infection (such as Salmonella, Listeria, Legionella pneumophia, etc.), including the regulation on growth, virulence and host iron levels is reviewed in this paper.
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Received: 21 April 2016
Published: 25 October 2016
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Corresponding Authors:
ZHANG Fengmin
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