Historically, the hazards during the outbreak of plague were extremely serious, and even affected the historical process. With the invention and widespread application of antibiotics, the plague-related mortality rate was significantly reduced. It is not necessary to panic about the plague. With the personal protection, it can be cured after the onset of illness. The prevention and control of plague needs to be treated separately according to the infected area or the non-epidemic area, which can effectively control the spread of the epidemic. Antibiotics such as fluoroquinolones and sulfonamides can effectively control the condition and can be used as a preventive medication after exposure.