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Abstract To provide reference for rational use of antibiotics in clinic, we investigate the distribution and antimicrobial resistance of pathogens causing bloodstream infection. The main pathogenic bacteria isolated from positive blood culture specimens and their antimicrobial resistance in our hospital from 2014 to 2021 were statistically analyzed. After eliminating the duplicate strains, a total of 1396 strains of pathogenic bacteria were detected in blood culture samples during the past eight years. The gram-negative bacteria, gram-positive bacteria and fungi account for 56.3%, 38.4% and 5.3%, respectively. The top eight strains were Escherichia coli accounting for 21.5% (300/1396), Coagulase negative Staphylococcus (CNS) accounting for 17.4% (243/1396), Klebsiella pneumoniae accounting for 14.9% (208/1396), Staphylococcus aureus accounting for 7.2% (100/1396), Acinetobacter baumannii accounting for 5.4% (76/1396), Enterococcus faecalis accounting for 4.2% (58/1396), Enterococcus faecium accounting for 3.7% (51/1396) and Pseudomonas aeruginosa accounting for 3.5% (49/1396). The resistance rate of Escherichia coli to third-generation cephalosporins exceeded 50%, and the resistance rate to carbapenems was as low as 1%; The resistance rate of Klebsiella pneumoniae to carbapenems was 46.3%; The cumulative resistance rate of Acinetobacter baumannii to cephalosporins, aminoglycosides and carbapenems was more than 45%; The cumulative rates of MRSA and CNS were 44.6% and 74.5%, respectively.
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Received: 30 August 2022
Published: 01 January 2023
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Corresponding Authors:
guo jian
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