Pemphigus patients have a higher risk of infections. The present paper aims to analyze the characteristics and risk factors of infections in pemphigus patients, and to provide guidance for clinical treatment and prevention. A total of 142 pemphigus patients hospitalized in Huashan Hospital, Fudan University from January 2017 to December 2021 were enrolled. The informations including infection rate, infection site and pathogen distribution were collected through medical records and laboratory results. Univariate analysis and multivariate Logistic regression analysis were performed to identify the risk factors of infections. There were 74 (52.1%) pemphigus patients with infections. Univariate analysis of risk factors showed that in the infection group 27.0% patients had hypoalbuminemia (P<0.001), 83.3% patients adopted systemic glucocorticoid treatment (P<0.001), and the patients in general used higher cumulative dose of glucocorticoids in the recent 3 months (P＝0.001). Multivariate Logistic regression analysis showed that hypoalbuminemia (OR＝7.96，95% CI is [1.95, 32.41]) and systemic glucocorticoid treatment (OR＝6.47，95% CI is [2.73, 15.33]) were risk factors of infections in pemphigus patients. The most susceptible sites of infections were wound surface and lung, and the most common pathogens were Staphylococcus aureus and Pseudomonas aeruginosa. It is suggested that hypoalbuminemia and systemic glucocorticoid treatment were risk factors of infections in pemphigus patients. Related measures should be taken as early as possible to prevent and control the infections.