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| Analysis of 8 cases of bloodstream infection with Bacteroides fragilis in cancer patients |
| ZHANG Xiaoyu1，2, ZHANG Li2, WU Weixing2, QI Jun2, WU Zongyong2, WANG Min1 |
| 1. Department of Laboratory Medicine, The Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, China; 2. National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Clinical Laboratory Department, Shenzhen 518116, Guangdong Province, China |
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Abstract Bacteroides fragilis (BF) is a symbiotic bacterium in human intestinal tract, and also an anaerobic bacterium with relatively high positive rate in clinical work. 11 strains of anaerobic bacteria isolated from 8 cancer patients from June 2020 to December 2021 were identified as Bacteroides fragilis by matrix-assisted laser desorption ionization time of flight mass spectrometry (MALDI-TOF MS ) technique. Analysis results of medical records showed that: five patients suffered with colorectal cancer; Surgery is the most common predisposing factor of Bacteroides fragilis bloodstream infetion (4/8); Imipenem and cilastatin sodium was selected for treatment in 4 patients, and the other 4 patients took other different types of antibiotics. Seven patients who effectively treated with antibiotics got controll of fever and infection. Their reexamination results of blood culture turned to be negative. This case analysis of bloodstream infection caused by Bacteroides fragilis in cancer patients can provide evidence for microbiology detection and clinical diagnosis and treatment.
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Received: 27 May 2022
Published: 25 August 2023
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Corresponding Authors:
WANG Min
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2023, Vol. 18 
