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| Advance and challenge in human immunodeficiency virus vaccine research and historic opportunity for China |
| SHAO Yi-Ming |
| Division of Research on Virology and Immunology, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China |
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Abstract After having gone through the bumpy road of the failure of first and second generations of human immunodeficiency virus ( HI V) vaccines , the first beamjust appeared recently . The goal of preventing HIV acquisitionis not unachievable , showing in the combined vaccine trial ( RV144) conducted in Thailand . With the progresses of obtaining better broad-spectrumneutralizing antibody and the development of its rystal structure , full protection achieved by genetic transferring of neutralizing antibodies , mosaic T cell epitope vaccines , as well as replicating viral vector vaccines , it is possible to achieve higher efficacy of vaccine protection. With the support of National Science and Technology Key Projects , scientists in the China HIV Vaccine Initiative are conducting innovative HI V vaccine research and also possible to make a big leap f orward , if seized the opportunity of international collaboration at the global and regional level .
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Received: 03 December 2010
Published: 25 December 2010
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Corresponding Authors:
SHAO Yi-Ming
E-mail: yshao08@gmail.com
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CHEN Qinyun1,2, WAN Yanmin1, DING Xiangqing 1,2, REN Yanqin1, XIAO Jian3, XU Jianqing1,2. Fusion expression of mouse IgG2b-Fc improves immunogenicity of human immunodeficiency virus type 1 Gag DNA vaccine[J]. JOURNAL OF MICROBES AND INFECTIONS, 2016, 11(2): 87-93. |
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