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| Antibiotic susceptibility of Staphylococcus aureus isolated from children with infectious skin diseases in China |
| YANG Zhou1; LIU Ying1; SUN Juan1; CHEN Ping2; CHEN Jin-Ping3; FENG Xiao-Bo4; Guo Yan-Ping5; LIU Qiang7; LIU Xiao-Feng8; LI Qin-Feng9; Ma Lin1; SONG Li10; TANG Jian-Ping12; WANG Yong-Ping6; WEI Feng-Lei11; XIAO Yi-Zhu13 |
| 1. Department of Dermatology, Beijing Children’s Hospital, Capital Medical University, Beijing 100045, China; 2. Department of Dermatology, Children’s Hospital of Xuzhou, Xuzhou 221006, China; 3. Department of Dermatology, Guangzhou Women and Children’s Medical Center, Guangzhou 510623, China; 4. Department of Dermatology, Xinhua Hospital, Shanghai Jiao Tong University School Of Medicine, Shanghai 200032, China; 5. Department of Dermatology, Harbin Children's Hospital, Harbin 150010, China; 6. Department of Dermatology, Changchun Children's Hospital, Changchun 130061, China; 7.Department of Dermatology, Shanxi Children's Hospital, Taiyuan 300013, China; 8. Department of Dermatology, Urumqi Children's Hospital, Urumqi 830011, China; 9. Department of Dermatology, Tianjin Children's Hospital, Tianjin 300074, China; 10. Department of Dermatology, Zhengzhou Children's Hospital, Zhengzhou 450053, China; 11. Department of Dermatology, Dalian Children's Hospital, Dalian 116001, China; 12. Department of Dermatology, Hunan Children's Hospital, Changsha 410007, China; 13. Department of Dermatology, Children's Hospital of Chongqing Medical University, Chongqing 400014, China |
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Abstract 1 043 Staphylococcus aureus (S. aureus) strains isolated from 1 416 skin lesions collected from children visiting the clinic for the first time with infectious skin diseases at thirteen Children’s Hospital in China were subjected to a drug susceptibility test by agar dilution method. The mecA gene and the genotypes of Staphylococcal chromosome cassette mec (SCCmec) were identified by polymerase chain reaction (PCR). The results demonstrated that the drug resistance rates were97.3% of the isolated s to erythromycin,96.7% to penicillin, 89% to clindamycin,42.2% to tetracycline, 15% to chloramphenicol, 9.8% to gentamicin, 6.6% to ciprofloxacin, 4.6% to trimethoprim/sulfamethoxazole, 3.4% to oxacillin, 3.1% to cefuroxime, 2.4% to rifampin, 1.7% to ceftriaxone, 1.6% to cefazolin, 1.3% to fusidic acid and 0.8% to mupirocin. None of the isolated S. aureus strains were resistant to vancomycin. The prevalence of community-acquired methicillin-resistant S. aureus (CA-MRSA) was 3.4%，and all the 35 strains were mecA-positive. SCCmec Ⅳ and V were identified in 14 and 19 isolates respectively.. Two isolates were non-typable. The results suggest that effective antibiotic agents for children with infectious skin diseases are oxacillin, cephalosporin, fusidic acid, trimethoprim/sulfamethoxazole, rifampin,and vancomycin. Mupirocin is the selection for topical application.The mecA gene was detected in 100% of 35 CA-MRSA strains from children with infectious skin diseases in China. SCCmec Ⅳ and SCCmec Ⅴ are the major genotype.
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Received: 24 November 2011
Published: 25 March 2012
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Corresponding Authors:
Ma Lin
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