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| Current research progress on human adenovirus type 36 and obesity |
| DONG Rui, GAO Xiao-Meng, SHI Jing-Jing, SHANG Qing-Long, GU Hong-Xi |
| Department of Microbiology, Harbin Medical University, Harbin 150081, China |
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Abstract The potential connection between human adenovirus type 36 (Ad-36) infection and obesity has received extensive research attentions in recent years. Studies indicated that Ad-36 antibody may be associated with body mass index (BMI) in obesity population, and the results were further confirmed in animal model and in vitro cellular models. Viral E4 orf-1 gene, cellular adipocyte differentiation pathway and phosphatidylinositol 3-kinase (PI3K) signaling pathways are current focal points of mechanism studies. Since limited data is available, more epidemiological data and mechanism studies are needed to confirm the relationship between Ad-36 infection and obesity.
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Received: 30 May 2012
Published: 01 January 2012
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Corresponding Authors:
GU Hong-Xi
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