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Progresses on the virulence mechanism of outer membrane protease T from Escherichia coli |
HUI Chang-Ye1, HUANG Sheng-He2, Cao Hong2, Zhang Yan-Fang1 |
1. Shenzhen Prevention and Treatment Center for Occupational Disease, Shenzhen 518001, China;2. Southern Medical University, Guangdong 510515, China |
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Abstract Uropathogenic Escherichia coli (UPEC) is the major cause of urinary tract infections worldwide. Outer membrane protease T (OmpT) , as a putative uropathogenic virulence factor , is found more frequently in UPEC than in fecal isolates. This review covers the current progress on substrate specificity of OmpT, resistance to cationic antimicrobial peptides, roles in the fibrinolytic system and bacterial adhesion and invasion.
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Received: 30 August 2012
Published: 25 December 2012
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Corresponding Authors:
HUI Chang-Ye
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