In order to investigate the current Helicobacter pylori (Hp) infection and the related factors , a self-designed questionnaire was distributed and collected from 723 patients who received Hp detection. The factors related to Hp infection were analyzed. The total Hp infection rate was 43.2%. A significant difference between male (50. 1 %) and female (34.9 %) ( P< 0.05 ) was observed. The results indicate that the factors related to Hp infection include education, stress, diet, physical exercise, water-drinking habits, health habits and digestive system disease , and consistent with published reports. Therefore , clinical detection of Hp and health education should be strengthened to prevent Hp infection.