微生物与感染
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Journal of Microbes and Infections
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Progress on research and treatment of melioidosis
FANG Jing1, FANG Yao2
1.General Department, Luotian First People’s Hospital, Hubei Province, Huanggang 438600, China; 2. Department of Clinical Microbiology and Immunology, Third Military Medical University, Chongqing 400038, China

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Abstract  Melioidosis, caused by the inoculation, inhalation and ingestion of Burkholderia pseudomallei, is a classical tropical amphixenosis characterized by multi-abscess , tough pneumonia and fatal septicemia. The mortality rate of this disease is up to 40%. Its endemic regions are mainly among North Australia, Southeast Asia, with sporadic cases reported from North America and other areas. Melioidosis may have a wide range of clinical manifestations, varying from an acute fulminant septic illness to a chronic infection. High misdiagnosis rate, high resistance rate and long period of antibiotic therarapy combined with high relapse rate are the major barriers to treatment . With the globalization and increasing risk of imported cases, it is necessary to effectively prevent and cure melioidosis. The current research progress and clinical advice are summarized in this paper.

Key wordsMelioidosis      Burkholderia pseudomallei      Diagnosis and therapy     
Received: 18 December 2012      Published: 25 June 2013
Corresponding Authors: FANG Yao   
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Cite this article:   
FANG Jing,FANG Yao. Progress on research and treatment of melioidosis[J]. Journal of Microbes and Infections, 2013, 8(2): 115-118.
URL:  
http://jmi.fudan.edu.cn/EN/      OR     http://jmi.fudan.edu.cn/EN/Y2013/V8/I2/115
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