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Study of adhesion-related glycosylphosphatidylinositol-anchored cell wall proteins in Candida species |
YAN Lei, TANG Jian-Guo |
Department of Trauma-Emergency & Critical Care Medicine, Shanghai Fifth People’s Hospital, Fudan University, Shanghai 200240, China |
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Abstract Candida species are the most prevalent opportunistic fungal pathogens in humans causing superficial and serious systemic infections. The infection process can be divided into three stages: adhesion, invasion, and host cell damage. Adhesion is the first stage of invasive Candida infection process and is precisely controlled by a lot of adhesins. Many of these adhesion-related proteins are members of glycosylphosphatidylinositol-anchored cell wall protein (GPI-CWP) family. This review is intended to summarize some important adhesion related to GPI-CWP: agglutinin-like sequence (Als), hyphal wall protein 1 (Hwp1), epithelial adhesin (Epa), and enhanced adherence to polystyrene 1 (Eap1).
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Received: 13 January 2013
Published: 01 January 2013
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Corresponding Authors:
TANG Jian-Guo
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