PDF(524 KB)
Study of adhesion-related glycosylphosphatidylinositol-anchored cell wall proteins in Candida species
YAN Lei, TANG Jian-Guo
Journal of Microbes and Infections ›› 2013, Vol. 8 ›› Issue (3) : 181-185.
PDF(524 KB)
PDF(524 KB)
Study of adhesion-related glycosylphosphatidylinositol-anchored cell wall proteins in Candida species
Candida species are the most prevalent opportunistic fungal pathogens in humans causing superficial and serious systemic infections. The infection process can be divided into three stages: adhesion, invasion, and host cell damage. Adhesion is the first stage of invasive Candida infection process and is precisely controlled by a lot of adhesins. Many of these adhesion-related proteins are members of glycosylphosphatidylinositol-anchored cell wall protein (GPI-CWP) family. This review is intended to summarize some important adhesion related to GPI-CWP: agglutinin-like sequence (Als), hyphal wall protein 1 (Hwp1), epithelial adhesin (Epa), and enhanced adherence to polystyrene 1 (Eap1).
Candida / Adhesin / Glycosylphosphatidylinositol-anchored cell wall protein / Pathogenicity
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