Study of adhesion-related glycosylphosphatidylinositol-anchored cell wall proteins in Candida species

YAN Lei, TANG Jian-Guo

Journal of Microbes and Infections ›› 2013, Vol. 8 ›› Issue (3) : 181-185.

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Journal of Microbes and Infections ›› 2013, Vol. 8 ›› Issue (3) : 181-185.
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Study of adhesion-related glycosylphosphatidylinositol-anchored cell wall proteins in Candida species

  • YAN Lei, TANG Jian-Guo
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Abstract

Candida species are the most prevalent opportunistic fungal pathogens in humans causing superficial and serious systemic infections. The infection process can be divided into three stages: adhesion, invasion, and host cell damage. Adhesion is the first stage of invasive Candida infection process and is precisely controlled by a lot of adhesins. Many of these adhesion-related proteins are members of glycosylphosphatidylinositol-anchored cell wall protein (GPI-CWP) family. This review is intended to summarize some important adhesion related to GPI-CWP: agglutinin-like sequence (Als), hyphal wall protein 1 (Hwp1), epithelial adhesin (Epa), and enhanced adherence to polystyrene 1 (Eap1).

Key words

Candida / Adhesin / Glycosylphosphatidylinositol-anchored cell wall protein / Pathogenicity

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YAN Lei, TANG Jian-Guo. Study of adhesion-related glycosylphosphatidylinositol-anchored cell wall proteins in Candida species[J]. Journal of Microbes and Infections. 2013, 8(3): 181-185
PDF(524 KB)

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