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Current research progress on acid resistance mechanism of Mycobacterium tuberculosis |
SHI Xu-Jun, WANG Qing-Lan, GAO Qian |
Key Laboratory of Medical Molecular Virology, Ministry of Education and Health, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China |
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Abstract The survival of Mycobacterium tuberculosis (M. tuberculosis) in the host is largely attributed to its ability to resist acidic environment within macrophages. M. tuberculosis inhibits the fusion of phagosomes with lysosomes, thus arresting the maturation and acidification process of phagosomes. Also, the bacterium resists the killing within the acidic phagosome-lysosome compartment. Here, the current understanding of the acidification of phagosomes and M. tuberculosis acid resistance mechanisms is reviewed.
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Received: 06 June 2013
Published: 01 January 2013
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Corresponding Authors:
GAO Qian
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