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Evaluation of a whole-blood interferon γ release assay for the diagnosis of tuberculosis in children and adults |
BAO Lei1, LI Tao2, LU Shui-Hua2 |
1.Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai 200040, China; 2. Shanghai Public Health Clinical Center Affiliated to Fudan University, Shanghai 201508, China |
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Abstract In order to evaluate the diagnostic value of the whole-blood interferon γ release assay (QuantiFERON TB Gold In-Tube test, QFT-GIT) in diagnosis of tuberculosis in children and adults in China (with a high rate of bacillus Calmette-Guérin vaccination and a high incidence of tuberculosis), 60 children and 60 adults with suspected tuberculosis were recruited for QFT-GIT test and clinical information collection. The results showed that among children, the sensitivity of QFT-GIT test was 83.87%, the specificity was 92%, positive predict value (PPV) was 92.86%, and negative predict value (NPV) was 82.14%. While among adults, the sensitivity of QFT-GIT test was 78.57%, the specificity was 84.62%, PPV was 84.62%, and NPV was 78.57%. Here comes a conclusion that QFT-GIT is of great value in diagnosis of tuberculosis, especially among children.
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Received: 04 March 2013
Published: 25 March 2014
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Corresponding Authors:
LU Shui-Hua
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[1] |
RUAN Qiao-Ling1, SHAO Ling-Yun1, WU Jing1, ZHANG Shu1, YU Sheng-Lei1, WANG Sen1, GAO Yan1, WANG Fei1, ZHANG Xi-Yan2, LIU Yuan-Yuan1, RAO Ying2, SHEN Yao-Jie1, ZHANG Ying1, ZHANG Wen-Hong1. Screening of tuberculosis infection in household contacts by interferon γ release assay and tuberculin skin test to predict active tuberculosis in China[J]. JOURNAL OF MICROBES AND INFECTIONS, 2015, 10(1): 28-33. |
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