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| Strategies for human immunodeficiency virus cure: current status and future prospects |
| LI Hao-Yang1,2，QU Yu-Chen1,2，WANG Qian1,2，JIANG Shi-Bo1,2,3, LU Lu1,2 |
| 1. Key Laboratory of Medical Molecular Virology of Ministries of Education and Health, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China; 2. Shanghai Public Health Clinical Center Affiliated to Fudan University, Shanghai 201508, China; 3. Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY 10065, USA |
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Abstract The combined antiretroviral therapy (cART) has been applied to control the course of human immunodeficiency virus (HIV) infection and acquired immunodeficiency syndrome (AIDS). However, cART requires lifelong daily treatment and strict adherence. HIV can quickly rebound after drug withdrawal because of the presence of the latent HIV reservoir in vivo. Therefore, reactivation of latent HIV and elimination of latent HIV reservoir are critical for cure of HIV infection and AIDS. Here, we review the recent advancements and future prospects on the strategies for HIV cure.
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Received: 09 September 2015
Published: 25 October 2015
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Corresponding Authors:
LU Lu,JIANG Shi-Bo
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